{"id":5900,"date":"2023-03-29T10:00:00","date_gmt":"2023-03-29T10:00:00","guid":{"rendered":"https:\/\/modernsciences.org\/staging\/4414\/?p=5900"},"modified":"2023-03-17T05:31:26","modified_gmt":"2023-03-17T05:31:26","slug":"how-we-created-the-first-map-of-an-insect-brain-and-what-it-means-for-our-understanding-of-the-human-brain","status":"publish","type":"post","link":"https:\/\/modernsciences.org\/staging\/4414\/how-we-created-the-first-map-of-an-insect-brain-and-what-it-means-for-our-understanding-of-the-human-brain\/","title":{"rendered":"How we created the first map of an insect brain \u2013 and what it means for our understanding of the human brain"},"content":{"rendered":"\n  <figure>\n    <img  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/images.theconversation.com\/files\/515734\/original\/file-20230316-24-oh3wlb.jpg?ixlib=rb-1.1.0&rect=9%2C14%2C3221%2C1918&q=45&auto=format&w=754&fit=clip\" >\n      <figcaption>\n        \n        <span class=\"attribution\"><a class=\"source\" href=\"https:\/\/www.shutterstock.com\/image-photo\/extreme-sharp-macro-portrait-fruit-fly-140164051\" target=\"_blank\" rel=\"noopener\">Tomatito\/Shutterstock<\/a><\/span>\n      <\/figcaption>\n  <\/figure>\n\n<span><a href=\"https:\/\/theconversation.com\/profiles\/michael-winding-1423742\" target=\"_blank\" rel=\"noopener\">Michael Winding<\/a>, <em><a href=\"https:\/\/theconversation.com\/institutions\/the-francis-crick-institute-5058\" target=\"_blank\" rel=\"noopener\">The Francis Crick Institute<\/a><\/em><\/span>\n\n<p>Imagine trying to navigate an unfamiliar city but you\u2019ve lost your smartphone. You don\u2019t have a map. And the street signs are in a foreign language. This is how neuroscientists feel about studying the brain. <\/p>\n\n<p>Billions of neurons in the human brain make <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK234146\/\" target=\"_blank\" rel=\"noopener\">trillions of connections<\/a> with each other, forming an intricate maze of roads (<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/neural-pathway\" target=\"_blank\" rel=\"noopener\">neural pathways<\/a>) that make us who we are. A neural pathway is a series of connected neurons that send signals from one part of the brain to another. These networks govern how we think, store our memories and interact with each other. <a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02208-0#:%7E:text=The%20human%20brain%20has%2010,required%20for%20such%20an%20endeavour.\" target=\"_blank\" rel=\"noopener\">Neuroscientists don\u2019t yet have the technology<\/a> to outline even a small fraction of the connections within the human brain. We have no map. <\/p>\n\n<p>But an international team of scientists at the <a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/\" target=\"_blank\" rel=\"noopener\">MRC Laboratory of Molecular Biology<\/a>, <a href=\"https:\/\/www.zoo.cam.ac.uk\/\" target=\"_blank\" rel=\"noopener\">University of Cambridge<\/a>, and <a href=\"https:\/\/www.bme.jhu.edu\/\" target=\"_blank\" rel=\"noopener\">Johns Hopkins University<\/a> has made a breakthrough. We mapped the most complex brain to date: an insect. This brain is in many ways similar to the human brain, with two hemispheres, a brainstem-like structure and a spinal cord equivalent that controls the animal\u2019s muscles. <\/p>\n\n<p>Understanding this brain may give us many clues about how the human brain works.<\/p>\n\n<figure>\n            <iframe loading=\"lazy\" width=\"440\" height=\"260\" src=\"https:\/\/www.youtube.com\/embed\/ZudHhIDG3M4?wmode=transparent&start=0\" frameborder=\"0\" allowfullscreen=\"\"><\/iframe>\n            \n          <\/figure>\n\n<p>There are only a few brain maps, or <a href=\"http:\/\/www.scholarpedia.org\/article\/Connectome\" target=\"_blank\" rel=\"noopener\">connectomes<\/a>, available today. Those that exist are for simple animals, such as <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4360118\/\" target=\"_blank\" rel=\"noopener\">worms<\/a> or <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5140264\/\" target=\"_blank\" rel=\"noopener\">sea squirts<\/a>, which have a few hundred neurons.<\/p>\n\n<p>You need expensive equipment to map brains, such as powerful <a href=\"https:\/\/www.britannica.com\/technology\/electron-microscope\" target=\"_blank\" rel=\"noopener\">electron microscopes<\/a> to image the tiny <a href=\"https:\/\/www.khanacademy.org\/science\/biology\/human-biology\/neuron-nervous-system\/a\/the-synapse\" target=\"_blank\" rel=\"noopener\">synapses between neurons<\/a>, each measuring roughly 10 billionth of a metre. Synapses are junctions where neurons communicate with each other. Even for simple brains, it takes years to reconstruct neural roadways, synapses and neurons.<\/p>\n\n<p>In a <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.add9330\" target=\"_blank\" rel=\"noopener\">recent study published in Science<\/a>, my co-authors and I mapped a fruit fly larva (<em>Drosophila melanogaster<\/em>) brain with 3,016 neurons and more than half a million synaptic sites. These insects are surprisingly complex. Fruit fly larvae <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aaw4099\" target=\"_blank\" rel=\"noopener\">can feel pain<\/a>, form good and bad memories, and <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0960982217309582\" target=\"_blank\" rel=\"noopener\">work in a team<\/a> with their neighbours to forage for food. <\/p>\n\n<h2 id=\"what-we-learned\">What we learned<\/h2>\n\n<p>The first thing we discovered was that fruit fly neurons communicate with each other in not one, but four different ways. <\/p>\n\n<figure class=\"align-center zoomable\">\n            <a href=\"https:\/\/images.theconversation.com\/files\/515249\/original\/file-20230314-1506-yi17s1.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip\" target=\"_blank\" rel=\"noopener\"><img  decoding=\"async\"  alt=\"\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-ls-sizes=\"(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px\"  data-pk-src=\"https:\/\/images.theconversation.com\/files\/515249\/original\/file-20230314-1506-yi17s1.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip\"  data-pk-srcset=\"https:\/\/images.theconversation.com\/files\/515249\/original\/file-20230314-1506-yi17s1.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=356&fit=crop&dpr=1 600w, https:\/\/images.theconversation.com\/files\/515249\/original\/file-20230314-1506-yi17s1.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=356&fit=crop&dpr=2 1200w, https:\/\/images.theconversation.com\/files\/515249\/original\/file-20230314-1506-yi17s1.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=356&fit=crop&dpr=3 1800w, https:\/\/images.theconversation.com\/files\/515249\/original\/file-20230314-1506-yi17s1.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=447&fit=crop&dpr=1 754w, https:\/\/images.theconversation.com\/files\/515249\/original\/file-20230314-1506-yi17s1.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=447&fit=crop&dpr=2 1508w, https:\/\/images.theconversation.com\/files\/515249\/original\/file-20230314-1506-yi17s1.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=447&fit=crop&dpr=3 2262w\" ><\/a>\n            <figcaption>\n              <span class=\"caption\">Anatomy of the neuron.<\/span>\n              <span class=\"attribution\"><a class=\"source\" href=\"https:\/\/www.shutterstock.com\/image-vector\/structure-motor-neuron-anatomy-brain-1507344530\" target=\"_blank\" rel=\"noopener\">logika600\/Shutterstock<\/a><\/span>\n            <\/figcaption>\n          <\/figure>\n\n<p>Scientists believed the main way neurons communicated with each other was using its cable (axon) to send neurotransmitters (chemical messengers) to the dendrite of another neuron. Dendrites are appendages designed to receive signals from other cells. However, this was only true for half of connections in the fruit fly larva brain. Sometimes, fruit fly neurons send messages from axon-to-axon, dendrite-to-dendrite, or dendrite-to-axon. <\/p>\n\n<p>Researchers were aware of <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2019.00570\/full\" target=\"_blank\" rel=\"noopener\">these kinds of connections<\/a>, but little was known about them or how many there were. Our team was shocked by the sheer number of them, which accounted for nearly half the brain\u2019s connectivity. They allowed neurons to connect with each other in ways we didn\u2019t consider before, for example, by combining multiple connection types simultaneously.<\/p>\n\n<figure class=\"align-center zoomable\">\n            <a href=\"https:\/\/images.theconversation.com\/files\/515245\/original\/file-20230314-22-jyn1a5.png?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip\" target=\"_blank\" rel=\"noopener\"><img  decoding=\"async\"  alt=\"\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-ls-sizes=\"(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px\"  data-pk-src=\"https:\/\/images.theconversation.com\/files\/515245\/original\/file-20230314-22-jyn1a5.png?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip\"  data-pk-srcset=\"https:\/\/images.theconversation.com\/files\/515245\/original\/file-20230314-22-jyn1a5.png?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=338&fit=crop&dpr=1 600w, https:\/\/images.theconversation.com\/files\/515245\/original\/file-20230314-22-jyn1a5.png?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=338&fit=crop&dpr=2 1200w, https:\/\/images.theconversation.com\/files\/515245\/original\/file-20230314-22-jyn1a5.png?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=338&fit=crop&dpr=3 1800w, https:\/\/images.theconversation.com\/files\/515245\/original\/file-20230314-22-jyn1a5.png?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=424&fit=crop&dpr=1 754w, https:\/\/images.theconversation.com\/files\/515245\/original\/file-20230314-22-jyn1a5.png?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=424&fit=crop&dpr=2 1508w, https:\/\/images.theconversation.com\/files\/515245\/original\/file-20230314-22-jyn1a5.png?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=424&fit=crop&dpr=3 2262w\" ><\/a>\n            <figcaption>\n              <span class=\"caption\">The fruit fly brain map.<\/span>\n              <span class=\"attribution\"><span class=\"source\">MRC Laboratory of Molecular Biology<\/span>, <span class=\"license\">Author provided<\/span><\/span>\n            <\/figcaption>\n          <\/figure>\n\n<p>Because there are so many neurons, it\u2019s difficult to think about the brain as one mass of interconnected neurons. So neuroscientists simplify things by grouping together similar \u201ccell types\u201d. Each neuron has a unique shape and role in the brain \u2014 essentially its own fingerprint. But there is no consensus about <a href=\"https:\/\/www.nature.com\/articles\/nrn.2017.85\" target=\"_blank\" rel=\"noopener\">how to define these cell types<\/a>. <\/p>\n\n<p>My team stumbled across a new way of breaking down brain structure into its simplest form, using the connections between neurons alone. We found 93 cell types across the fruit fly larva brain. Neurons within each of these groups had similar shapes and performed similar roles in the brain, for example, receiving visual information from the eye. <\/p>\n\n<p>Next, we focused on the core of the brain in more detail. We developed an algorithm that tracks signals across the brain. Scientists thought <a href=\"https:\/\/www.nature.com\/articles\/nrn2619\" target=\"_blank\" rel=\"noopener\">different neurons were dedicated to different senses<\/a> and these signals only later came together. But, using our algorithm, we discovered most neurons multitask, performing different roles depending on the particular sensory cues the fruit fly larva is experiencing. Neurons that processed only one sensory signal were rare.  <\/p>\n\n<h2 id=\"algorithms-and-brains\">Algorithms and brains<\/h2>\n\n<p>The fruit fly larva brain showed astonishing similarities with artificial intelligence (AI). Pathways through the brain were layered <a href=\"https:\/\/datagen.tech\/guides\/computer-vision\/resnet\/#:%7E:text=Residual%20Network%20(ResNet)%20is%20a,or%20thousands%20of%20convolutional%20layers.\" target=\"_blank\" rel=\"noopener\">on top of each other like ResNets<\/a>, (artificial neural networks that allow <a href=\"https:\/\/www.sciencedirect.com\/topics\/engineering\/deep-neural-network\" target=\"_blank\" rel=\"noopener\">deep networks<\/a> to better learn tasks), allowing it to pack more power. Many brain pathways contained loops. This was shown particularly in the learning and memory centre, perhaps functioning like a <a href=\"https:\/\/en.wikipedia.org\/wiki\/Recurrent_neural_network\" target=\"_blank\" rel=\"noopener\">recurrent neural network<\/a> (artificial neural networks with looping connections). <\/p>\n\n<p>But even simple brains can perform many tasks well, while AI can only do a good job of one task. Plus, brains are much more efficient, using far less energy than AI. If a brain used enough energy to power a lightbulb to solve a problem, AI might need the energy required <a href=\"https:\/\/www.technologyreview.com\/2019\/06\/06\/239031\/training-a-single-ai-model-can-emit-as-much-carbon-as-five-cars-in-their-lifetimes\/\" target=\"_blank\" rel=\"noopener\">to build and drive five cars for 120,000 miles<\/a> to figure out the same puzzle.<\/p>\n\n<p>AI is becoming more commonplace, with breakthroughs <a href=\"https:\/\/openai.com\/blog\/chatgpt\" target=\"_blank\" rel=\"noopener\">like ChatGPT<\/a>. This technology is becoming <a href=\"https:\/\/www.numenta.com\/blog\/2022\/05\/24\/ai-is-harming-our-planet\/\" target=\"_blank\" rel=\"noopener\">increasingly energy hungry<\/a>, with the potential to worsen the current climate crisis. Learning how brains can solve complex problems with minimal energy use will be essential to reduce the carbon footprint of AI.<\/p>\n\n<p>My team\u2019s study is a milestone in understanding the structures of brains. Because fruit flies share many genes with humans, our fruit fly larva brain map may help scientists learn how disease-causing mutations change brain wiring in neurological conditions, such as autism spectrum disorders and schizophrenia. <\/p>\n\n<p>With a brain map in hand, answers to questions about brain function and dysfunction are within reach. All we need to do is keep exploring.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img  loading=\"lazy\"  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  alt=\"The Conversation\"  width=\"1\"  height=\"1\"  style=\"border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important\"  referrerpolicy=\"no-referrer-when-downgrade\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/counter.theconversation.com\/content\/201826\/count.gif?distributor=republish-lightbox-basic\" ><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https:\/\/theconversation.com\/republishing-guidelines --><\/p>\n\n<p><span><a href=\"https:\/\/theconversation.com\/profiles\/michael-winding-1423742\" target=\"_blank\" rel=\"noopener\">Michael Winding<\/a>, Group Leader, <em><a href=\"https:\/\/theconversation.com\/institutions\/the-francis-crick-institute-5058\" target=\"_blank\" rel=\"noopener\">The Francis Crick Institute<\/a><\/em><\/span><\/p>\n\n<p>This article is republished from <a href=\"https:\/\/theconversation.com\" target=\"_blank\" rel=\"noopener\">The Conversation<\/a> under a Creative Commons license. Read the <a href=\"https:\/\/theconversation.com\/how-we-created-the-first-map-of-an-insect-brain-and-what-it-means-for-our-understanding-of-the-human-brain-201826\" target=\"_blank\" rel=\"noopener\">original article<\/a>.<\/p>\n\n","protected":false},"excerpt":{"rendered":"Tomatito\/Shutterstock Michael Winding, The Francis Crick Institute Imagine trying to navigate an unfamiliar city but you\u2019ve lost your&hellip;\n","protected":false},"author":417,"featured_media":5891,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[11],"tags":[278,461,474],"class_list":{"0":"post-5900","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-nature","8":"tag-brain","9":"tag-insect","10":"tag-the-conversation","11":"cs-entry","12":"cs-video-wrap"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/5900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/users\/417"}],"replies":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/comments?post=5900"}],"version-history":[{"count":1,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/5900\/revisions"}],"predecessor-version":[{"id":5901,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/5900\/revisions\/5901"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media\/5891"}],"wp:attachment":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media?parent=5900"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/categories?post=5900"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/tags?post=5900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}