{"id":4921,"date":"2022-10-20T10:00:00","date_gmt":"2022-10-20T10:00:00","guid":{"rendered":"https:\/\/modernsciences.org\/staging\/4414\/?p=4921"},"modified":"2022-10-05T10:13:39","modified_gmt":"2022-10-05T10:13:39","slug":"whats-next-for-ancient-dna-studies-after-nobel-prize-honors-groundbreaking-field-of-paleogenomics","status":"publish","type":"post","link":"https:\/\/modernsciences.org\/staging\/4414\/whats-next-for-ancient-dna-studies-after-nobel-prize-honors-groundbreaking-field-of-paleogenomics\/","title":{"rendered":"What\u2019s next for ancient DNA studies after Nobel Prize honors groundbreaking field of\u00a0paleogenomics"},"content":{"rendered":"\n  <figure>\n    <img  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/images.theconversation.com\/files\/488157\/original\/file-20221004-14-rupej6.jpg?ixlib=rb-1.1.0&#038;rect=360%2C291%2C4414%2C3088&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip\" >\n      <figcaption>\n        Researchers need to be careful not to contaminate ancient samples with their own DNA.\n        <span class=\"attribution\"><a class=\"source\" href=\"https:\/\/www.gettyimages.com\/detail\/photo\/female-scientist-filling-pipette-trays-at-fume-hood-royalty-free-image\/1374565126\" target=\"_blank\" rel=\"noopener\">Caia Image via Getty Images<\/a><\/span>\n      <\/figcaption>\n  <\/figure>\n\n<span><a href=\"https:\/\/theconversation.com\/profiles\/mary-prendergast-683378\" target=\"_blank\" rel=\"noopener\">Mary Prendergast<\/a>, <em><a href=\"https:\/\/theconversation.com\/institutions\/rice-university-931\" target=\"_blank\" rel=\"noopener\">Rice University<\/a><\/em><\/span>\n\n<p>For the first time, a Nobel Prize recognized the field of anthropology, the study of humanity. Svante P\u00e4\u00e4bo, a pioneer in the study of ancient DNA, or aDNA, was awarded the 2022 <a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2022\/summary\/\" target=\"_blank\" rel=\"noopener\">prize in physiology or medicine<\/a> for his breathtaking achievements sequencing DNA extracted from ancient skeletal remains and reconstructing early humans\u2019 genomes \u2013 that is, all the genetic information contained in one organism.<\/p>\n\n<p>His accomplishment was once only the stuff of Jurassic Park-style science fiction. But P\u00e4\u00e4bo and many colleagues, working in large multidisciplinary teams, <a href=\"https:\/\/theconversation.com\/nobel-prize-svante-paabos-ancient-dna-discoveries-offer-clues-as-to-what-makes-us-human-191805\" target=\"_blank\" rel=\"noopener\">pieced together the genomes<\/a> of our distant cousins, the famous Neanderthals and the more elusive Denisovans, whose existence was not even known until their <a href=\"https:\/\/www.nytimes.com\/2010\/12\/23\/science\/23ancestor.html\" target=\"_blank\" rel=\"noopener\">DNA was sequenced<\/a> from a tiny pinky bone of a child <a href=\"https:\/\/theconversation.com\/fresh-clues-to-the-life-and-times-of-the-denisovans-a-little-known-ancient-group-of-humans-110504\" target=\"_blank\" rel=\"noopener\">buried in a cave in Siberia<\/a>. Thanks to interbreeding with <a href=\"https:\/\/theconversation.com\/ancient-teenager-the-first-known-person-with-parents-of-two-different-species-101965\" target=\"_blank\" rel=\"noopener\">and among<\/a> these early humans, their genetic traces <a href=\"https:\/\/theconversation.com\/neanderthals-died-out-40-000-years-ago-but-there-has-never-been-more-of-their-dna-on-earth-189021\" target=\"_blank\" rel=\"noopener\">live on in many of us today<\/a>, shaping our bodies and our disease vulnerabilities \u2013 for example, to <a href=\"https:\/\/doi.org\/10.1073\/pnas.2026309118\" target=\"_blank\" rel=\"noopener\">COVID-19<\/a>.<\/p>\n\n<p><iframe loading=\"lazy\" id=\"5Fzpd\" class=\"tc-infographic-datawrapper\" src=\"https:\/\/datawrapper.dwcdn.net\/5Fzpd\/2\/\" height=\"400px\" width=\"100%\" style=\"border: none\" frameborder=\"0\"><\/iframe><\/p>\n\n<p>The world has learned a startling amount about <a href=\"https:\/\/theconversation.com\/six-recent-discoveries-that-have-changed-how-we-think-about-human-origins-190274\" target=\"_blank\" rel=\"noopener\">our human origins<\/a> in the last dozen years since P\u00e4\u00e4bo and teammates\u2019 groundbreaking discoveries. And the field of paleogenomics has rapidly expanded. Scientists have now sequenced <a href=\"https:\/\/theconversation.com\/we-sequenced-the-oldest-ever-dna-from-million-year-old-mammoths-155485\" target=\"_blank\" rel=\"noopener\">mammoths that lived a million years ago<\/a>. Ancient DNA has addressed questions ranging from the origins of the <a href=\"https:\/\/www.sapiens.org\/archaeology\/ancient-dna-native-americans\/\" target=\"_blank\" rel=\"noopener\">first Americans<\/a> to the domestication of <a href=\"https:\/\/www.smithsonianmag.com\/smart-news\/genetic-sequencing-pinpoints-the-origins-of-the-domestic-horse-180978926\/\" target=\"_blank\" rel=\"noopener\">horses<\/a> and <a href=\"https:\/\/bigthink.com\/the-past\/ancient-dogs\/\" target=\"_blank\" rel=\"noopener\">dogs<\/a>, the spread of <a href=\"https:\/\/theconversation.com\/ancient-dna-is-revealing-the-origins-of-livestock-herding-in-africa-114387\" target=\"_blank\" rel=\"noopener\">livestock herding<\/a> and our bodies\u2019 adaptations \u2013 or lack thereof \u2013 to <a href=\"https:\/\/www.newscientist.com\/article\/2331213-evolution-of-lactose-tolerance-probably-driven-by-famine-and-disease\/\" target=\"_blank\" rel=\"noopener\">drinking milk<\/a>. Ancient DNA can even shed light on <a href=\"https:\/\/doi.org\/10.1073\/pnas.2120786119\" target=\"_blank\" rel=\"noopener\">social questions<\/a> of marriage, kinship and mobility. Researchers can now sequence DNA not only from the remains of ancient humans, animals and plants, but even from their <a href=\"https:\/\/theconversation.com\/digging-deep-dna-molecules-in-ancient-dirt-offer-a-treasure-trove-of-clues-to-our-past-172489\" target=\"_blank\" rel=\"noopener\">traces left in cave dirt<\/a>.<\/p>\n\n<p>Alongside this growth in research, people have been grappling with <a href=\"https:\/\/theconversation.com\/ancient-dna-unearths-fascinating-secrets-but-what-about-the-ethics-85186\" target=\"_blank\" rel=\"noopener\">concerns about the speed<\/a> with which skeletal collections around the world have been sampled for aDNA, leading to broader conversations about <a href=\"https:\/\/theconversation.com\/rights-of-the-dead-and-the-living-clash-when-scientists-extract-dna-from-human-remains-94284\" target=\"_blank\" rel=\"noopener\">how research should be done<\/a>. Who should conduct it? Who may benefit from or be harmed by it, and who gives consent? And how can the field become more equitable? As an <a href=\"https:\/\/scholar.google.com\/citations?user=3QKcZMoAAAAJ&amp;hl=en&amp;oi=ao\" target=\"_blank\" rel=\"noopener\">archaeologist<\/a> who partners with geneticists to study <a href=\"https:\/\/theconversation.com\/ancient-dna-helps-reveal-social-changes-in-africa-50-000-years-ago-that-shaped-the-human-story-175436\" target=\"_blank\" rel=\"noopener\">ancient African history<\/a>, I see both challenges and opportunities ahead.<\/p>\n\n<h2 id=\"building-a-better-discipline\">Building a better discipline<\/h2>\n\n<p>One positive sign: Interdisciplinary researchers are working to establish <a href=\"https:\/\/theconversation.com\/why-scholars-have-created-global-guidelines-for-ancient-dna-research-169284\" target=\"_blank\" rel=\"noopener\">basic common guidelines<\/a> for research design and conduct.<\/p>\n\n<p>In North America, scholars have worked to address inequities by designing programs that <a href=\"https:\/\/www.singconsortium.org\/\" target=\"_blank\" rel=\"noopener\">train future generations of Indigenous geneticists<\/a>. These are now expanding to other historically underrepresented communities in the world. In museums, <a href=\"https:\/\/doi.org\/10.1073\/pnas.1822038116\" target=\"_blank\" rel=\"noopener\">best practices for sampling<\/a> are being put into place. They aim to minimize destruction to ancestral remains, while gleaning the most new information possible.<\/p>\n\n<p><iframe loading=\"lazy\" id=\"ucxNW\" class=\"tc-infographic-datawrapper\" src=\"https:\/\/datawrapper.dwcdn.net\/ucxNW\/4\/\" height=\"400px\" width=\"100%\" style=\"border: none\" frameborder=\"0\"><\/iframe><\/p>\n\n<p>But there is a long way to go to develop and enforce community consultation, ethical sampling and data sharing policies, especially in more resource-constrained parts of the world. The divide <a href=\"https:\/\/doi.org\/10.3389\/fgene.2022.880170\" target=\"_blank\" rel=\"noopener\">between the developing world and rich industrialized nations<\/a> is especially stark when looking at where <a href=\"https:\/\/www.google.com\/maps\/d\/viewer?mid=1qwXOKV5uoQntgBsxQrxS01YHpbs&amp;ll=-3.81666561775622e-14%2C6.726945455479381&amp;z=1\" target=\"_blank\" rel=\"noopener\">ancient DNA labs<\/a>, funding and research publications are concentrated. It leaves fewer opportunities for scholars from parts of Asia, Africa and the Americas to be trained in the field and lead research. <\/p>\n\n<p>The field faces structural challenges, such as the relative lack of funding for archaeology and cultural heritage protection in lower income countries, worsened by a <a href=\"https:\/\/theconversation.com\/archaeology-is-changing-slowly-but-its-still-too-tied-up-in-colonial-practices-133243\" target=\"_blank\" rel=\"noopener\">long history of extractive research practices<\/a> and looming <a href=\"https:\/\/doi.org\/10.1038\/s41558-022-01280-1\" target=\"_blank\" rel=\"noopener\">climate change and site destruction<\/a>. These issues strengthen the regional bias in paleogenomics, which helps explain why some parts of the world \u2013 such as Europe \u2013 are so well-studied, while Africa \u2013 the <a href=\"https:\/\/theconversation.com\/ancient-dna-increases-the-genetic-time-depth-of-modern-humans-84716\" target=\"_blank\" rel=\"noopener\">cradle of humankind<\/a> and the <a href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-019-1740-1\" target=\"_blank\" rel=\"noopener\">most genetically diverse continent<\/a> \u2013 is relatively understudied, with shortfalls in <a href=\"https:\/\/www.theguardian.com\/commentisfree\/2022\/jan\/03\/africa-humanity-heritage-archaeologist\" target=\"_blank\" rel=\"noopener\">archaeology<\/a>, <a href=\"https:\/\/www.nature.com\/articles\/d44148-022-00051-6\" target=\"_blank\" rel=\"noopener\">genomics<\/a> and <a href=\"https:\/\/www.discovermagazine.com\/planet-earth\/with-ancient-human-dna-africas-deep-history-is-coming-to-light\" target=\"_blank\" rel=\"noopener\">ancient DNA<\/a>.<\/p>\n\n<h2 id=\"making-public-education-a-priority\">Making public education a priority<\/h2>\n\n<p>How paleogenomic findings are interpreted and communicated to the public <a href=\"https:\/\/www.nature.com\/articles\/s41559-019-0961-8\" target=\"_blank\" rel=\"noopener\">raises other concerns<\/a>. Consumers are regularly bombarded with advertisements for personal ancestry testing, <a href=\"https:\/\/blogs.ancestry.com\/cm\/goodbye-lederhosen-hello-kilt-how-a-dna-test-changed-one-mans-identity-forever\/\" target=\"_blank\" rel=\"noopener\">implying that genetics and identity are synonymous<\/a>. But lived experiences and decades of scholarship show that biological ancestry and socially defined identities <a href=\"https:\/\/theconversation.com\/genetic-ancestry-tests-dont-change-your-identity-but-you-might-98663\" target=\"_blank\" rel=\"noopener\">do not map so easily onto one another<\/a>.<\/p>\n\n<p>I\u2019d argue that scholars studying aDNA have a responsibility to work with educational institutions, like schools and museums, to communicate the meaning of their research to the public. This is particularly important because people with political agendas \u2013 <a href=\"https:\/\/www.smithsonianmag.com\/history\/when-ancient-dna-gets-politicized-180972639\/\" target=\"_blank\" rel=\"noopener\">even elected officials<\/a> \u2013 <a href=\"https:\/\/theconversation.com\/white-supremacists-believe-in-genetic-purity-science-shows-no-such-thing-exists-146763\" target=\"_blank\" rel=\"noopener\">try to manipulate findings<\/a>.<\/p>\n\n<p>For example, white supremacists have <a href=\"https:\/\/www.nytimes.com\/2018\/10\/19\/us\/white-supremacists-science-genetics.html\" target=\"_blank\" rel=\"noopener\">erroneously equated lactose tolerance with whiteness<\/a>. It\u2019s a falsehood that would be laughable to many livestock herders from Africa, one of the multiple <a href=\"https:\/\/www.the-scientist.com\/daily-news\/origins-of-lactase-persistence-in-africa-37810\" target=\"_blank\" rel=\"noopener\">centers of origin<\/a> for genetic traits enabling people to digest milk.<\/p>\n\n<figure class=\"align-center zoomable\">\n            <a href=\"https:\/\/images.theconversation.com\/files\/308159\/original\/file-20191221-11900-1i8iio9.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip\" target=\"_blank\" rel=\"noopener\"><img  decoding=\"async\"  alt=\"\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-ls-sizes=\"(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px\"  data-pk-src=\"https:\/\/images.theconversation.com\/files\/308159\/original\/file-20191221-11900-1i8iio9.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip\"  data-pk-srcset=\"https:\/\/images.theconversation.com\/files\/308159\/original\/file-20191221-11900-1i8iio9.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=505&amp;fit=crop&amp;dpr=1 600w, https:\/\/images.theconversation.com\/files\/308159\/original\/file-20191221-11900-1i8iio9.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=505&amp;fit=crop&amp;dpr=2 1200w, https:\/\/images.theconversation.com\/files\/308159\/original\/file-20191221-11900-1i8iio9.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=505&amp;fit=crop&amp;dpr=3 1800w, https:\/\/images.theconversation.com\/files\/308159\/original\/file-20191221-11900-1i8iio9.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=635&amp;fit=crop&amp;dpr=1 754w, https:\/\/images.theconversation.com\/files\/308159\/original\/file-20191221-11900-1i8iio9.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=635&amp;fit=crop&amp;dpr=2 1508w, https:\/\/images.theconversation.com\/files\/308159\/original\/file-20191221-11900-1i8iio9.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=635&amp;fit=crop&amp;dpr=3 2262w\" ><\/a>\n            <figcaption>\n              <span class=\"caption\">The 2010 excavation in the East Gallery of Denisova Cave, where the ancient hominin species known as the Denisovans was discovered.<\/span>\n              <span class=\"attribution\"><span class=\"source\">Bence Viola. Dept. of Anthropology, University of Toronto<\/span>, <a class=\"license\" href=\"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/\" target=\"_blank\" rel=\"noopener\">CC BY-ND<\/a><\/span>\n            <\/figcaption>\n          <\/figure>\n\n<h2 id=\"leaning-in-at-the-interdisciplinary-table\">Leaning in at the interdisciplinary table<\/h2>\n\n<p>Finally, there\u2019s a discussion to be had about how <a href=\"https:\/\/theconversation.com\/ancient-dna-is-a-powerful-tool-for-studying-the-past-when-archaeologists-and-geneticists-work-together-111127\" target=\"_blank\" rel=\"noopener\">specialists in different disciplines should work together<\/a>.<\/p>\n\n<p>Ancient DNA research has grown rapidly, sometimes without sufficient conversations happening beyond the genetics labs. This oversight has provoked a <a href=\"https:\/\/www.nature.com\/articles\/d41586-018-03773-6\" target=\"_blank\" rel=\"noopener\">backlash<\/a> from archaeologists, anthropologists, historians and linguists. Their disciplines have generated decades or even centuries of research that shape ancient DNA interpretations, and their labor makes paleogenomic studies possible.<\/p>\n\n<p>As an archaeologist, I see the aDNA \u201crevolution\u201d as usefully disrupting our practice. It prompts the archaeological community to reevaluate <a href=\"https:\/\/www.sapiens.org\/archaeology\/south-africa-repatriation\/\" target=\"_blank\" rel=\"noopener\">where ancestral skeletal collections come from and should rest<\/a>. It challenges us to publish archaeological data that is sometimes only revealed for the first time in the supplements of paleogenomics papers. It urges us to grab a seat at the table and help drive projects from their inception. We can design research grounded in archaeological knowledge, and may have longer-term and stronger ties to museums and to local communities, whose partnership is key to doing research right.<\/p>\n\n<p>If archaeologists embrace this moment that P\u00e4\u00e4bo\u2019s Nobel Prize is spotlighting, and lean in to the sea changes rocking our field, it can change for the better.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img  loading=\"lazy\"  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  alt=\"The Conversation\"  width=\"1\"  height=\"1\"  style=\"border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important\"  referrerpolicy=\"no-referrer-when-downgrade\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/counter.theconversation.com\/content\/191899\/count.gif?distributor=republish-lightbox-basic\" ><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https:\/\/theconversation.com\/republishing-guidelines --><\/p>\n\n<p><span><a href=\"https:\/\/theconversation.com\/profiles\/mary-prendergast-683378\" target=\"_blank\" rel=\"noopener\">Mary Prendergast<\/a>, Associate Professor of Anthropology, <em><a href=\"https:\/\/theconversation.com\/institutions\/rice-university-931\" target=\"_blank\" rel=\"noopener\">Rice University<\/a><\/em><\/span><\/p>\n\n<p>This article is republished from <a href=\"https:\/\/theconversation.com\" target=\"_blank\" rel=\"noopener\">The Conversation<\/a> under a Creative Commons license. Read the <a href=\"https:\/\/theconversation.com\/whats-next-for-ancient-dna-studies-after-nobel-prize-honors-groundbreaking-field-of-paleogenomics-191899\" target=\"_blank\" rel=\"noopener\">original article<\/a>.<\/p>\n\n","protected":false},"excerpt":{"rendered":"Researchers need to be careful not to contaminate ancient samples with their own DNA. Caia Image via Getty&hellip;\n","protected":false},"author":238,"featured_media":4908,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[12,11],"tags":[294,309,474],"class_list":{"0":"post-4921","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health-and-body","8":"category-nature","9":"tag-dna","10":"tag-nobel-prize","11":"tag-the-conversation","12":"cs-entry","13":"cs-video-wrap"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/4921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/users\/238"}],"replies":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/comments?post=4921"}],"version-history":[{"count":1,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/4921\/revisions"}],"predecessor-version":[{"id":4922,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/4921\/revisions\/4922"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media\/4908"}],"wp:attachment":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media?parent=4921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/categories?post=4921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/tags?post=4921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}