{"id":4310,"date":"2022-06-12T22:00:00","date_gmt":"2022-06-12T22:00:00","guid":{"rendered":"https:\/\/modernsciences.org\/staging\/4414\/?p=4310"},"modified":"2022-06-01T07:42:16","modified_gmt":"2022-06-01T07:42:16","slug":"what-are-hela-cells-a-cancer-biologist-explains","status":"publish","type":"post","link":"https:\/\/modernsciences.org\/staging\/4414\/what-are-hela-cells-a-cancer-biologist-explains\/","title":{"rendered":"What are HeLa cells? A cancer biologist\u00a0explains"},"content":{"rendered":"\n  <figure>\n    <img  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/images.theconversation.com\/files\/465571\/original\/file-20220526-14-aez4rh.jpg?ixlib=rb-1.1.0&#038;rect=0%2C0%2C1022%2C771&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip\" >\n      <figcaption>\n        Cancer-causing viruses like HPV can cause cells to divide indefinitely and, in the case of Henrietta Lacks, become immortal.\n        <span class=\"attribution\"><a class=\"source\" href=\"https:\/\/flic.kr\/p\/A5Q7L1\" target=\"_blank\" rel=\"noopener\">Tom Deerinck\/NIH via Flickr<\/a>, <a class=\"license\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\" target=\"_blank\" rel=\"noopener\">CC BY-NC<\/a><\/span>\n      <\/figcaption>\n  <\/figure>\n\n<span><a href=\"https:\/\/theconversation.com\/profiles\/ivan-martinez-1280764\" target=\"_blank\" rel=\"noopener\">Ivan Martinez<\/a>, <em><a href=\"https:\/\/theconversation.com\/institutions\/west-virginia-university-1375\" target=\"_blank\" rel=\"noopener\">West Virginia University<\/a><\/em><\/span>\n\n<p>In an amazing twist of fate, the aggressive cervical cancer tumor that killed <a href=\"https:\/\/www.npr.org\/2010\/02\/02\/123232331\/henrietta-lacks-a-donors-immortal-legacy\" target=\"_blank\" rel=\"noopener\">Henrietta Lacks<\/a>, a 31-year old African American mother, became an <a href=\"https:\/\/osp.od.nih.gov\/scientific-sharing\/hela-cells-timeline\/\" target=\"_blank\" rel=\"noopener\">essential tool<\/a> that helped the biomedical field flourish in the 20th century. As a <a href=\"https:\/\/www.researchgate.net\/scientific-contributions\/Ivan-Martinez-2109620653\" target=\"_blank\" rel=\"noopener\">cancer researcher<\/a> who uses HeLa cells in my everyday work, even I sometimes find it hard to believe.   <\/p>\n\n<p>Lacks\u2019 cervical cancer cells, called \u201cHeLa\u201d after the first two letters of her first and last name, are <a href=\"https:\/\/www.science.org\/content\/article\/art-culture-developing-cell-lines\" target=\"_blank\" rel=\"noopener\">immortal<\/a>, continuing to divide when most cells would die. This ability to survive through endless generations of cells is what makes them invaluable for scientists conducting experiments on human cells.<\/p>\n\n<h2 id=\"why-hela-cells-matter\">Why HeLa cells matter<\/h2>\n\n<p>Before HeLa cells, scientists wanted a way to grow and study human cells in the lab to conduct studies that are impossible to do in a living person. When Lacks\u2019 cervical cancer cells were <a href=\"https:\/\/osp.od.nih.gov\/scientific-sharing\/hela-cells-landing\/\" target=\"_blank\" rel=\"noopener\">successfully grown in a petri dish in 1951<\/a>, scientists now had a source of cost-effective and easy-to-use cells that expanded their ability to conduct research. From <a href=\"https:\/\/doi.org\/10.1084\/jem.97.5.695\" target=\"_blank\" rel=\"noopener\">polio<\/a> and <a href=\"https:\/\/doi.org\/10.1016\/j.cell.2020.07.024\" target=\"_blank\" rel=\"noopener\">COVID-19 vaccines<\/a> to <a href=\"https:\/\/doi.org\/10.1002\/jcp.22917\" target=\"_blank\" rel=\"noopener\">cancer research<\/a> and <a href=\"https:\/\/doi.org\/10.1534\/g3.113.005777\" target=\"_blank\" rel=\"noopener\">sequencing the human genome<\/a>, HeLa cells have played an enormous role in many scientific discoveries and advancements.<\/p>\n\n<p>Henrietta Lacks\u2019 story is also an <a href=\"https:\/\/www.wgbh.org\/news\/local-news\/2022\/05\/17\/thermo-fisher-seeks-dismissal-of-henrietta-lacks-familys-lawsuit-regarding-sale-of-her-cells\" target=\"_blank\" rel=\"noopener\">ongoing bioethics case<\/a>, because these cells were taken from her during a routine cervical cancer biopsy that was then given to researchers without her consent, as was <a href=\"https:\/\/doi.org\/10.1146%2Fannurev-genom-083115-022536\" target=\"_blank\" rel=\"noopener\">common practice<\/a> at the time. The Lacks family has <a href=\"https:\/\/www.washingtonpost.com\/local\/legal-issues\/henrietta-lacks-family-sues-company\/2021\/10\/04\/810ffa6c-2531-11ec-8831-a31e7b3de188_story.html\" target=\"_blank\" rel=\"noopener\">long attempted legal action<\/a> against companies they say have unfairly benefited from Henrietta\u2019s cells. A <a href=\"https:\/\/www.npr.org\/2010\/02\/02\/123232331\/henrietta-lacks-a-donors-immortal-legacy\" target=\"_blank\" rel=\"noopener\">2010 book<\/a> by journalist Rebecca Skloot details how HeLa cells affected both science and the Lacks family.<\/p>\n\n<figure>\n            <iframe loading=\"lazy\" width=\"440\" height=\"260\" src=\"https:\/\/www.youtube.com\/embed\/T3kR2dMCfOM?wmode=transparent&amp;start=0\" frameborder=\"0\" allowfullscreen=\"\"><\/iframe>\n            <figcaption><span class=\"caption\">The Lacks family wasn\u2019t aware that Henrietta\u2019s cells had been harvested until Rolling Stone magazine journalist Michael Rogers contacted them two decades after her death.<\/span><\/figcaption>\n          <\/figure>\n\n<p>But how did Lacks\u2019 cells become immortal?<\/p>\n\n<p>Lacks didn\u2019t know that cells in her cervix were infected with a virus that causes one of the most common sexually transmitted diseases: <a href=\"https:\/\/www.cdc.gov\/std\/hpv\/default.htm\" target=\"_blank\" rel=\"noopener\">human papillomavirus<\/a>, or HPV. There are more than 150 different types of HPVs, but only a small group are known to cause <a href=\"https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/infectious-agents\/hpv-and-cancer\" target=\"_blank\" rel=\"noopener\">cervical cancer<\/a>. In fact, <a href=\"https:\/\/doi.org\/10.1002\/(SICI)1096-9896(199909)189:1%3C12::AID-PATH431%3E3.0.CO;2-F\" target=\"_blank\" rel=\"noopener\">99.7% of cervical cancers<\/a> are HPV positive. Fortunately, most people infected with high-risk HPVs are able to clear out the virus before it becomes cancerous. <a href=\"https:\/\/www.cdc.gov\/vaccines\/vpd\/hpv\/public\/index.html\" target=\"_blank\" rel=\"noopener\">HPV vaccinations<\/a> can prevent over 90% of HPV-related cancers. But <a href=\"https:\/\/www.cdc.gov\/cancer\/hpv\/basic_info\/index.htm\" target=\"_blank\" rel=\"noopener\">10% of people<\/a> with HPV infections on their cervix develop cancer. Sadly, Henrietta was one of the unlucky ones.<\/p>\n\n<p>Her misfortune has helped elucidate how HPV works. Since the <a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2008\/hausen\/facts\/\" target=\"_blank\" rel=\"noopener\">Nobel Prize-winning<\/a> 1976 discovery of <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/175942\" target=\"_blank\" rel=\"noopener\">HPV\u2019s essential role<\/a> in cervical cancer, many scientists, including me, have been investigating how HPV <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK9929\/\" target=\"_blank\" rel=\"noopener\">causes cancer<\/a>.<\/p>\n\n<figure>\n            <iframe loading=\"lazy\" width=\"440\" height=\"260\" src=\"https:\/\/www.youtube.com\/embed\/SPezZ6qKGFw?wmode=transparent&amp;start=0\" frameborder=\"0\" allowfullscreen=\"\"><\/iframe>\n            <figcaption><span class=\"caption\">While some types of HPV cause warts on the skin, certain high-risk ones can cause cancer.<\/span><\/figcaption>\n          <\/figure>\n\n<h2 id=\"two-proteins\">Two proteins<\/h2>\n\n<p>Turns out, the virus\u2019 cancer-causing ability is linked to two proteins it produces. These viral proteins can <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1322242\/\" target=\"_blank\" rel=\"noopener\">target and destroy<\/a> two major human proteins that protect against cancer, <a href=\"https:\/\/doi.org\/10.1038\/s41598-019-40094-8\" target=\"_blank\" rel=\"noopener\">p53 and retinoblastoma (Rb)<\/a>. P53 and Rb act as sentinels making sure cells don\u2019t accumulate harmful genetic mutations and stop dividing after a set number of cycles. My research has focused on how HPV proteins interact with <a href=\"https:\/\/doi.org\/10.1038\/s41598-019-40094-8\" target=\"_blank\" rel=\"noopener\">tumor-suppressing<\/a> <a href=\"https:\/\/doi.org\/10.1073\/pnas.1017346108\" target=\"_blank\" rel=\"noopener\">proteins<\/a> in different types of human cells, including HeLa.<\/p>\n\n<p>Most cells divide around <a href=\"https:\/\/doi.org\/10.1016\/0014-4827(65)90211-9\" target=\"_blank\" rel=\"noopener\">40 to 60 times<\/a> before they become too old to function properly and are naturally killed off. But HPV can allow cells to divide forever, because they attack the sentinels keeping uncontrolled division in check. After Lacks was infected with <a href=\"https:\/\/doi.org\/10.1128\/JVI.01747-15\" target=\"_blank\" rel=\"noopener\">HPV 18<\/a>, the second-most-common high-risk type of the virus, her cervical cells lost the ability to produce these sentinels. Without growth checks in place, her cells were able to divide indefinitely and became \u201cimmortal\u201d \u2013 living on to this day both in test tubes and the <a href=\"https:\/\/www.immunology.org\/hela-cells-1951\" target=\"_blank\" rel=\"noopener\">70,000 studies<\/a> they\u2019ve made possible.<\/p>\n\n<p><em>Read other short, accessible explanations of newsworthy subjects written by academics in their areas of expertise for The Conversation U.S. <a href=\"https:\/\/theconversation.com\/us\/topics\/significant-terms-105996\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/em><!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img  loading=\"lazy\"  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  alt=\"The Conversation\"  width=\"1\"  height=\"1\"  style=\"border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/counter.theconversation.com\/content\/169913\/count.gif?distributor=republish-lightbox-basic\" ><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https:\/\/theconversation.com\/republishing-guidelines --><\/p>\n\n<p><span><a href=\"https:\/\/theconversation.com\/profiles\/ivan-martinez-1280764\" target=\"_blank\" rel=\"noopener\">Ivan Martinez<\/a>, Associate Professor of Microbiology, Immunology and Cell Biology, <em><a href=\"https:\/\/theconversation.com\/institutions\/west-virginia-university-1375\" target=\"_blank\" rel=\"noopener\">West Virginia University<\/a><\/em><\/span><\/p>\n\n<p>This article is republished from <a href=\"https:\/\/theconversation.com\" target=\"_blank\" rel=\"noopener\">The Conversation<\/a> under a Creative Commons license. Read the <a href=\"https:\/\/theconversation.com\/what-are-hela-cells-a-cancer-biologist-explains-169913\" target=\"_blank\" rel=\"noopener\">original article<\/a>.<\/p>\n\n","protected":false},"excerpt":{"rendered":"Cancer-causing viruses like HPV can cause cells to divide indefinitely and, in the case of Henrietta Lacks, become&hellip;\n","protected":false},"author":89,"featured_media":4311,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[12],"tags":[268,545,474],"class_list":{"0":"post-4310","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health-and-body","8":"tag-cancer","9":"tag-hela-cell","10":"tag-the-conversation","11":"cs-entry","12":"cs-video-wrap"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/4310","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/users\/89"}],"replies":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/comments?post=4310"}],"version-history":[{"count":1,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/4310\/revisions"}],"predecessor-version":[{"id":4312,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/4310\/revisions\/4312"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media\/4311"}],"wp:attachment":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media?parent=4310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/categories?post=4310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/tags?post=4310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}