{"id":14724,"date":"2025-06-05T10:00:00","date_gmt":"2025-06-05T10:00:00","guid":{"rendered":"https:\/\/modernsciences.org\/staging\/4414\/?p=14724"},"modified":"2025-05-30T12:17:37","modified_gmt":"2025-05-30T12:17:37","slug":"remote-gene-expression-control-nanoparticle-technology-june-2025","status":"publish","type":"post","link":"https:\/\/modernsciences.org\/staging\/4414\/remote-gene-expression-control-nanoparticle-technology-june-2025\/","title":{"rendered":"New Nanoparticle Technology Enables Remote Control of Gene Expression in Living Organisms"},"content":{"rendered":"\n<div class=\"wp-block-group has-gray-200-background-color has-background\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h1 id=\"at-a-glance\" class=\"wp-block-heading\">At a Glance<\/h1>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"\">Scientists at ETH Zurich have developed a method to control gene expression in living organisms using magnetic fields. This method offers a noninvasive alternative to conventional drug delivery methods.<\/li>\n\n\n\n<li class=\"\">When exposed to low-frequency magnetic fields, the system uses multiferroic nanoparticles coated in chitosan that generate reactive oxygen species, triggering therapeutic protein production inside engineered cells.<\/li>\n\n\n\n<li class=\"\">In diabetic mice, daily short-term exposure to magnetic fields successfully activated insulin release, effectively maintaining stable blood glucose levels without requiring injections.<\/li>\n\n\n\n<li class=\"\">This technology enables remote, non-invasive treatment control and holds promise for managing chronic diseases like diabetes more efficiently and comfortably for patients.<\/li>\n\n\n\n<li class=\"\">Pending further optimization and clinical trials, researchers believe the technique could revolutionize cancer treatment, neurology, and tissue regeneration therapies.<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"\">Researchers from <a href=\"https:\/\/ethz.ch\/en.html\" target=\"_blank\" rel=\"noreferrer noopener\">ETH Zurich<\/a> have developed a groundbreaking technique that allows scientists to control gene expression in living organisms using magnetic fields, offering a non-invasive solution for medical treatments. This technique could be a game-changer in managing diseases like diabetes, as it allows for precise control over protein production without requiring surgery or drug injections. By using nanoparticles that respond to low-frequency magnetic fields, the team has found a way to trigger the release of therapeutic proteins, such as insulin, in living organisms.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  alt=\"\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2025\/a-nanoparticle-cell-in-3.jpg\" ><figcaption class=\"wp-element-caption\">An electromagnetic coil was used in the study to generate the low-frequency magnetic fields that activate the specialized nanoparticles. These fields trigger the nanoparticles to initiate gene expression for therapeutic protein production in living organisms. (Lin et al., 2025)<\/figcaption><\/figure>\n\n\n\n<p class=\"\">The nanoparticles used in this study are made of multiferroic materials and coated with a biocompatible chitosan polymer. When exposed to a weak magnetic field, these nanoparticles generate reactive oxygen species (ROS) within cells. ROS are naturally occurring molecules that play a role in cell signaling. The team engineered mammalian cells to be sensitive to these ROS signals, which activate proteins in the cells to produce therapeutic proteins like insulin.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  alt=\"\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2025\/a-nanoparticle-cell-in-2.jpg\" ><figcaption class=\"wp-element-caption\">Microscopic images revealing the composition of the specialized nanoparticles. They show the distribution of Cobalt (Co, purple) and Bismuth (Bi, blue) \u2013 key elements of the multiferroic core \u2013 and Nitrogen (N, green), which indicates the biocompatible chitosan coating. The far-right dark-field image displays the overall nanoparticle cluster used to remotely control gene expression. (Lin et al., 2025)<\/figcaption><\/figure>\n\n\n\n<p class=\"\">In a mouse model of diabetes, the researchers showed that they could control insulin secretion by exposing the animals to a weak electromagnetic field for just a few minutes each day. This approach was highly effective, keeping the mice\u2019s blood glucose levels stable throughout the study. The key advantage of this method is that it is non-invasive and can be controlled remotely, which could reduce the need for regular injections or surgeries for patients with chronic conditions like diabetes.<\/p>\n\n\n\n<p class=\"\">The team\u2019s findings, published in <a href=\"https:\/\/www.nature.com\/articles\/s41565-025-01929-w\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Nature Nanotechnology<\/em><\/a>, represent a significant step forward in biomedical research, opening the door for new, more personalized, and dynamic treatments. This technology could be applied to various medical fields, including oncology, neurology, and regenerative medicine. Researchers are continuing to refine the system to make it even more efficient and ready for clinical use, which could dramatically improve the management of chronic diseases.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 id=\"references\" class=\"wp-block-heading\">References<\/h1>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"\">Lin, Z., Guha Ray, P., Huang, J., Buchmann, P., &amp; Fussenegger, M. (2025). Electromagnetic wireless remote control of mammalian transgene expression. <em>Nature Nanotechnology<\/em>. <a href=\"https:\/\/doi.org\/10.1038\/s41565-025-01929-w\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1038\/s41565-025-01929-w<\/a><\/li>\n\n\n\n<li class=\"\">Fadelli, I. &amp; Phys.org. (2025, May 18). <em>Nanoparticle-cell interface enables electromagnetic wireless programming of mammalian transgene expression<\/em>. Phys.Org; Phys.org. <a href=\"https:\/\/phys.org\/news\/2025-05-nanoparticle-cell-interface-enables-electromagnetic.html\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/phys.org\/news\/2025-05-nanoparticle-cell-interface-enables-electromagnetic.html<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"\"><\/p>\n\n\n\n<p class=\"\"><\/p>\n\n\n\n<p class=\"\"><\/p>\n","protected":false},"excerpt":{"rendered":"Scientists have developed magnetically responsive nanoparticles that remotely trigger gene expression, offering a non-invasive way to control protein production like insulin in living organisms.\n","protected":false},"author":4,"featured_media":14726,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","fifu_image_url":"https:\/\/images.pexels.com\/photos\/17485658\/pexels-photo-17485658\/free-photo-of-an-artist-s-illustration-of-artificial-intelligence-ai-this-image-depicts-how-ai-could-adapt-to-an-infinite-amount-of-uses-it-was-created-by-nidia-dias-as-part-of-the-visualising-ai-pr.png?auto=compress&cs=tinysrgb&w=1260&h=750&dpr=2","fifu_image_alt":"","footnotes":""},"categories":[15,11],"tags":[11386,11391,11396,11384,11392,11395,11387,11393,11385,11388,11390,11383,11397,11389,11394],"class_list":{"0":"post-14724","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-engineering","8":"category-nature","9":"tag-chitosan-coated-nanoparticles","10":"tag-diabetes-nanoparticle-treatment","11":"tag-electromagnetic-field-biomedical-therapy","12":"tag-eth-zurich-magnetic-nanoparticles","13":"tag-gene-regulation-with-magnetic-fields","14":"tag-insulin-secretion-mouse-model","15":"tag-magnetic-field-gene-activation","16":"tag-multiferroic-material-biotechnology","17":"tag-nanoparticle-gene-therapy","18":"tag-non-invasive-insulin-delivery","19":"tag-personalized-medicine-nanoparticles","20":"tag-remote-gene-expression-control","21":"tag-remote-controlled-medical-treatments","22":"tag-ros-triggered-protein-production","23":"tag-therapeutic-protein-release-technology","24":"cs-entry","25":"cs-video-wrap"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/14724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/comments?post=14724"}],"version-history":[{"count":1,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/14724\/revisions"}],"predecessor-version":[{"id":14725,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/14724\/revisions\/14725"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media\/14726"}],"wp:attachment":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media?parent=14724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/categories?post=14724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/tags?post=14724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}