{"id":11914,"date":"2024-05-29T22:00:00","date_gmt":"2024-05-29T22:00:00","guid":{"rendered":"https:\/\/modernsciences.org\/staging\/4414\/?p=11914"},"modified":"2024-05-17T06:31:11","modified_gmt":"2024-05-17T06:31:11","slug":"unlocking-the-bodys-defences-understanding-immunotherapy","status":"publish","type":"post","link":"https:\/\/modernsciences.org\/staging\/4414\/unlocking-the-bodys-defences-understanding-immunotherapy\/","title":{"rendered":"Unlocking the body\u2019s defences: understanding immunotherapy"},"content":{"rendered":"\n<div class=\"theconversation-article-body\">\n    <figure>\n      <img  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/images.theconversation.com\/files\/588034\/original\/file-20240415-16-rhx5p8.jpg?ixlib=rb-4.1.0&#038;rect=26%2C26%2C5964%2C3961&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip\" >\n        <figcaption>\n          \n          <span class=\"attribution\"><a class=\"source\" href=\"https:\/\/www.shutterstock.com\/image-photo\/gene-therapy-cancer-treatment-concept-tcell-591898805\" target=\"_blank\" rel=\"noopener\">CI Photos\/Shutterstock<\/a><\/span>\n        <\/figcaption>\n    <\/figure>\n\n  <span><a href=\"https:\/\/theconversation.com\/profiles\/justin-stebbing-1405462\" target=\"_blank\" rel=\"noopener\">Justin Stebbing<\/a>, <em><a href=\"https:\/\/theconversation.com\/institutions\/anglia-ruskin-university-1887\" target=\"_blank\" rel=\"noopener\">Anglia Ruskin University<\/a><\/em><\/span>\n\n  <p>In the battle against diseases, the human body boasts an intricate defence network capable of identifying and neutralising threats \u2013 the <a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2022.984678\/full\" target=\"_blank\" rel=\"noopener\">immune system<\/a>.\nIt serves as a guardian, constantly patrolling the body to keep it safe from invaders like bacteria, viruses, and even cancer cells.<\/p>\n\n<p>Scientists are harnessing the power of the body\u2019s natural defence mechanism to develop immunotherapy, <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.359.6382.1344\" target=\"_blank\" rel=\"noopener\">revolutionising<\/a> the landscape of medical treatment. It enhances, redirects, or restores the body\u2019s immune response to recognise and eliminate abnormal cells, such as cancer cells or those responsible for autoimmune diseases like multiple sclerosis, rheumatoid arthritis and type 1 diabetes. <\/p>\n\n<p>Immunotherapy, however, is expensive. So, chemotherapy and radiation therapy are still the primary cancer treatments for most patients. But these conventional methods can damage healthy tissues as well as abnormal cells. They also tend to have debilitating <a href=\"https:\/\/www.nhs.uk\/conditions\/chemotherapy\/side-effects\/\" target=\"_blank\" rel=\"noopener\">side effects<\/a>, such as nausea, vomiting, tiredness and hair loss. <\/p>\n\n<p>Immunotherapy uses the body\u2019s immune system to combat diseases with precision and minimal harm by blocking molecules \u2013 called checkpoint inhibitors \u2013 like <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26558876\/\" target=\"_blank\" rel=\"noopener\">PD-L1 or CTLA-4<\/a> that cancer cells use to turn off the immune systems. <\/p>\n\n<figure>\n            <iframe loading=\"lazy\" width=\"440\" height=\"260\" src=\"https:\/\/www.youtube.com\/embed\/Dm3O1D8EMQk?wmode=transparent&amp;start=0\" frameborder=\"0\" allowfullscreen=\"\"><\/iframe>\n            \n          <\/figure>\n\n<p><a href=\"https:\/\/www.oncology.ox.ac.uk\/blog\/cancer-immunologists-win-nobel-prize-in-medicine\" target=\"_blank\" rel=\"noopener\">Checkpoint inhibitors<\/a> are a <a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2018\/press-release\/\" target=\"_blank\" rel=\"noopener\">Nobel prize<\/a>-winning discovery and they\u2019re now one of the most widely used forms of immunotherapy. They work by blocking surface proteins that prevent immune cells from attacking cancer cells. By lifting the brakes on the immune response, these inhibitors unleash the body\u2019s natural defence mechanism against cancer.<\/p>\n\n<h2 id=\"hot-and-cold-tumours\">Hot and cold tumours<\/h2>\n\n<p>Tumours are often <a href=\"https:\/\/jitc.biomedcentral.com\/articles\/10.1186\/s40425-018-0479-7\" target=\"_blank\" rel=\"noopener\">categorised<\/a> as \u201chot\u201d or \u201ccold\u201d based on their interaction with the immune system. <\/p>\n\n<p>Hot tumours are characterised by a robust immune response, with infiltrating immune cells actively engaging with cancer cells. In contrast, cold tumours exhibit minimal immune activity, often evading detection by the immune system. <\/p>\n\n<p>Immunotherapy has worked in hot tumours such as melanoma, kidney cancer and <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34636350\/\" target=\"_blank\" rel=\"noopener\">lung<\/a> cancers. However, many tumours \u2013 such as most types of <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2023.41.4_suppl.LBA8\" target=\"_blank\" rel=\"noopener\">colon cancer<\/a> \u2013 <a href=\"https:\/\/ascopost.com\/issues\/february-10-2019\/turning-cold-tumors-into-hot-ones\/\" target=\"_blank\" rel=\"noopener\">respond poorly<\/a> to immunotherapy because they\u2019re able to evade immune surveillance. <\/p>\n\n<figure>\n            <iframe loading=\"lazy\" width=\"440\" height=\"260\" src=\"https:\/\/www.youtube.com\/embed\/8Y-x-rDvEU4?wmode=transparent&amp;start=0\" frameborder=\"0\" allowfullscreen=\"\"><\/iframe>\n            \n          <\/figure>\n\n<p>However, immunotherapies are <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37937212\/\" target=\"_blank\" rel=\"noopener\">emerging<\/a> that could expand the benefits to <a href=\"https:\/\/www.nature.com\/articles\/s41388-023-02835-y\" target=\"_blank\" rel=\"noopener\">more cancer patients<\/a>, including those with cold tumours. These approaches include combination therapies using more effective immune checkpoint inhibitors with other agents, including chemotherapy and drugs in trials, to prime the immune system and enhance tumour recognition.<\/p>\n\n<p>There are other approaches too.<\/p>\n\n<h2 id=\"car-t-cell-therapy\">CAR-T cell therapy<\/h2>\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-023-05707-3\" target=\"_blank\" rel=\"noopener\">CAR-T cell therapy<\/a> involves extracting a patient\u2019s immune cells and genetically engineering them to produce <a href=\"https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/chimeric-antigen-receptor\" target=\"_blank\" rel=\"noopener\">chimeric antigen receptors<\/a> \u2013 proteins on the surface of the immune cells that recognise cancer \u2013 before reintroducing them into the bloodstream. Once inside the body, the modified immune cells target and destroy cancer cells. This treatment has been used in tumour conditions <a href=\"https:\/\/www.nature.com\/articles\/s41571-023-00832-4\" target=\"_blank\" rel=\"noopener\">like<\/a> lymphomas or leukaemias but now these are moving into <a href=\"https:\/\/www.nature.com\/articles\/s41571-023-00754-1\" target=\"_blank\" rel=\"noopener\">other cancer types<\/a>.<\/p>\n\n<h2 id=\"invariant-natural-killer-cells\">Invariant natural killer cells<\/h2>\n\n<p>A 2024 <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-44905-z\" target=\"_blank\" rel=\"noopener\">trial<\/a> used \u201cinvariant natural killer cells\u201d, which help coordinate the body\u2019s immune response, as <a href=\"https:\/\/www.telegraph.co.uk\/news\/2024\/02\/07\/new-cancer-drug-could-improve-prognosis-covid-patients\/\" target=\"_blank\" rel=\"noopener\">immunotherapy<\/a> during very severe infections, when people affected by a viral attack on their lungs could no longer breathe. The trial found that most patients recovered despite being critically unwell. <\/p>\n\n<p>Unlike traditional vaccines that prevent infectious diseases, cancer vaccines stimulate the immune system to recognise and attack cancer cells. Cancer vaccines may contain tumour-specific markers called <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14604955\/\" target=\"_blank\" rel=\"noopener\">antigens or genetic material<\/a> to <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15059610\/\" target=\"_blank\" rel=\"noopener\">train<\/a> the immune system to <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16925480\/\" target=\"_blank\" rel=\"noopener\">target<\/a> cancerous cells.<\/p>\n\n<p>This means that immunotherapy can offer truly personalised medicine. There\u2019s data, for example, on cancer vaccines from <a href=\"https:\/\/theconversation.com\/pancreatic-cancer-a-personalised-mrna-vaccine-may-boost-effects-of-treatment-205606\" target=\"_blank\" rel=\"noopener\">clinical trials<\/a> based on the changes or mutations of a specific patient\u2019s tumour. <\/p>\n\n<h2 id=\"benefits-beyond-cancer-treatment\">Benefits beyond cancer treatment<\/h2>\n\n<p>While immunotherapy has gained widespread recognition for its efficacy in cancer treatment, its applications could extend <a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06243-w\" target=\"_blank\" rel=\"noopener\">far beyond oncology<\/a>. By harnessing the immune system\u2019s ability to distinguish self from non-self, immunotherapy offers promising avenues for combating a diverse range of ailments.<\/p>\n\n<p>For example, researchers are exploring its potential in treating <a href=\"https:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2308917\" target=\"_blank\" rel=\"noopener\">autoimmune<\/a> diseases, allergic disorders, infectious diseases, and even neurological conditions like <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9503401\/\" target=\"_blank\" rel=\"noopener\">Alzheimer\u2019s<\/a> disease. <\/p>\n\n<p>The treatment can be highly effective but it\u2019s not everyone. For reasons we don\u2019t yet fully understand, some people are resistant to treatment. Immunotherapy isn\u2019t free of side effects either. Autoimmune complications can include <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35470301\/\" target=\"_blank\" rel=\"noopener\">colon<\/a> and <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35123465\/\" target=\"_blank\" rel=\"noopener\">lung<\/a> tissue inflammation. The current high cost of immunotherapy can prove prohibitive for many potential patients. Additionally, uptake of the treatment is limited by patient selection \u2013 choosing who would most benefit from this treatment and developing personalised treatment regimens remain critical for maximising results.<\/p>\n\n<p>Ongoing research into immunotherapy could herald an era of targeted and tailored treatments. These include <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36631681\/\" target=\"_blank\" rel=\"noopener\">oncolytic viruses<\/a> that can attack cancer directly, and <a href=\"https:\/\/ehoonline.biomedcentral.com\/articles\/10.1186\/s40164-023-00442-x\" target=\"_blank\" rel=\"noopener\">microbiome<\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.1091124\/full\" target=\"_blank\" rel=\"noopener\">modulation<\/a>, which uses bacteria to enhance the activity of checkpoint inhibitors.<\/p>\n\n<figure>\n            <iframe loading=\"lazy\" width=\"440\" height=\"260\" src=\"https:\/\/www.youtube.com\/embed\/htl4452LijI?wmode=transparent&amp;start=0\" frameborder=\"0\" allowfullscreen=\"\"><\/iframe>\n            \n          <\/figure>\n\n<p>As our understanding of immunology continues to deepen and technology advances, immunotherapy could offer precision medicine and personalised treatments for a host of previously incurable conditions \u2013 the challenge is to make it available and accessible to more patients.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img  loading=\"lazy\"  decoding=\"async\"  src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEUAAP+KeNJXAAAAAXRSTlMAQObYZgAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAApJREFUCNdjYAAAAAIAAeIhvDMAAAAASUVORK5CYII=\"  alt=\"The Conversation\"  width=\"1\"  height=\"1\"  style=\"border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important\"  referrerpolicy=\"no-referrer-when-downgrade\"  class=\" pk-lazyload\"  data-pk-sizes=\"auto\"  data-pk-src=\"https:\/\/counter.theconversation.com\/content\/226858\/count.gif?distributor=republish-lightbox-basic\" ><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https:\/\/theconversation.com\/republishing-guidelines --><\/p>\n\n  <p><span><a href=\"https:\/\/theconversation.com\/profiles\/justin-stebbing-1405462\" target=\"_blank\" rel=\"noopener\">Justin Stebbing<\/a>, Professor of Biomedical Sciences, <em><a href=\"https:\/\/theconversation.com\/institutions\/anglia-ruskin-university-1887\" target=\"_blank\" rel=\"noopener\">Anglia Ruskin University<\/a><\/em><\/span><\/p>\n\n  <p>This article is republished from <a href=\"https:\/\/theconversation.com\" target=\"_blank\" rel=\"noopener\">The Conversation<\/a> under a Creative Commons license. Read the <a href=\"https:\/\/theconversation.com\/unlocking-the-bodys-defences-understanding-immunotherapy-226858\" target=\"_blank\" rel=\"noopener\">original article<\/a>.<\/p>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"CI Photos\/Shutterstock Justin Stebbing, Anglia Ruskin University In the battle against diseases, the human body boasts an intricate&hellip;\n","protected":false},"author":832,"featured_media":11916,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","fifu_image_url":"https:\/\/drive.google.com\/uc?id=1zavkx_apzzGcOc8_eaX6f-m-UsqFX-cR","fifu_image_alt":"","footnotes":""},"categories":[12],"tags":[463,1405,474,89],"class_list":{"0":"post-11914","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health-and-body","8":"tag-immune-system","9":"tag-immunotherapy","10":"tag-the-conversation","11":"tag-therapy","12":"cs-entry","13":"cs-video-wrap"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/11914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/users\/832"}],"replies":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/comments?post=11914"}],"version-history":[{"count":1,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/11914\/revisions"}],"predecessor-version":[{"id":11915,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/posts\/11914\/revisions\/11915"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media\/11916"}],"wp:attachment":[{"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/media?parent=11914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/categories?post=11914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/modernsciences.org\/staging\/4414\/wp-json\/wp\/v2\/tags?post=11914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}